Natural selection favoring more transmissible HIV detected in United States molecular transmission network.

HIV molecular epidemiology can identify clusters of individuals with elevated rates of HIV transmission. These variable transmission rates are primarily driven by host risk behavior; however, the effect of viral traits on variable transmission rates is poorly understood. Viral load, the concentration of HIV in blood, is a heritable viral trait that influences HIV infectiousness and disease progression. Here, we reconstruct HIV genetic transmission clusters using data from the United States National HIV Surveillance System and report that viruses in clusters, inferred to be frequently transmitted, have higher viral loads at diagnosis. Further, viral load is higher in people in larger clusters and with increased network connectivity, suggesting that HIV in the United States is experiencing natural selection to be more infectious and virulent. We also observe a concurrent increase in viral load at diagnosis over the last decade. This evolutionary trajectory may be slowed by prevention strategies prioritized toward rapidly growing transmission clusters

An independent constraint on the secular rate of variation of the gravitational constant from pulsating white dwarfs

A secular variation of the gravitational constant modifies the structure and evolutionary time scales of white dwarfs. Using an state-of-the-art stellar evolutionary code and an up-to-date pulsational code we compute the effects of a secularly varying $G$ on the pulsational properties of variable white dwarfs. Comparing the the theoretical results obtained taking into account the effects of a running $G$ with the observed periods and measured rates of change of the periods of two well studied pulsating white dwarfs, G117--B15A and R548, we place constraints on the rate of variation of Newton's constant. We derive an upper bound $\dot G/G\sim -1.8\times 10^{-10}$ yr$^{-1}$ using the variable white dwarf G117--B15A, and $\dot G/G\sim -1.3\times 10^{-10}$ yr$^{-1}$ using R548. Although these upper limits are currently less restrictive than those obtained using other techniques, they can be improved in a future measuring the rate of change of the period of massive white dwarfs.Comment: 13 pages, 4 tables, 3 figures. To be published in the Journal of Cosmology and Astroparticle Physic

Examining Evolutionary Rate in Xiphosura

Horseshoe crabs, a group of aquatic chelicerate arthropods of the class Xiphosura, are strongly linked with the concept of “living fossils” – a term colloquially used to refer to clades that display a consistently low rate of morphological evolution through time. The concept of living fossils has been hotly debated, as it is considered to simplify or obscure millennia of evolutionary change. Recent methodological and computational advances in the paleobiological sciences have allowed for the investigation of these claims. Xiphosura are a model taxon for this type of investigative study because they exhibit a complex evolutionary history, despite their reputation as “living fossils”. Xiphosura first appear in the fossil record during the Ordovician and are represented today by four extant species. During these 480 million years of evolution, Xiphosura have displayed a remarkably stable body plan, most notably in Limulidae, the sole surviving clade from the Mesozoic onwards; however, there are also aberrant forms associated with the exploration of nonmarine niches. The presence of these forms in the fossil record indicates a more complex evolutionary history than is usually attributed to Xiphosura, including events of both rapid evolutionary change and stasis. A comprehensive study of evolutionary rate in horseshoe crabs through their fossil record has not yet been conducted. Thus, their status as a clade with consistently low rate of evolution has not been evaluated. An investigation of evolutionary rates in Xiphosura using discrete character data reveals heterogeneous rates of evolution; specifically, high rates of evolution cluster within Belinurina and Austrolimulidae – two clades that display heterochronic morphological trends and affinities for non-marine environments. Additionally, these high evolutionary rates occur after the transition to nonmarine habitats, indicating a driving environmental pull behind shifts to heterochronic morphologies. Conversely, the clades that show no concerted heterochronic trends – Limulidae and Paleolimulidae – produced varied high and low rates, with a tendency towards lower rates of discrete character evolution. Xiphosura also show variable rates of evolution through time, with higher rates corresponding to mass extinction events and radiations. Average evolutionary rate in Xiphosura has also decreased through time, though there is still variability present. Overall, horseshoe crabs show variable and dynamic evolutionary patterns through time, therefore indicating that they are not “living fossils.

An explanation for the curious mass loss history of massive stars: from OB stars, through Luminous Blue Variables to Wolf-Rayet stars

The stellar winds of massive stars show large changes in mass-loss rates and terminal velocities during their evolution from O-star through the Luminous Blue Variable phase to the Wolf-Rayet phase. The luminosity remains approximately unchanged during these phases. These large changes in wind properties are explained in the context of the radiation driven wind theory, of which we consider four different models. They are due to the evolutionary changes in radius, gravity and surface composition and to the change from optically thin (in continuum) line driven winds to optically thick radiation driven winds.Comment: Accepted for publication in Astronomy and Astrophysics (Letter to the Editor

A genome-wide survey of changes in protein evolutionary rates across four closely related species of Saccharomyces sensu stricto group

BACKGROUND: Changes in protein evolutionary rates among lineages have been frequently observed during periods of notable phenotypic evolution. It is also known that, following gene duplication and loss, the protein evolutionary rates of genes involved in such events changed because of changes in functional constraints acting on the genes. However, in the evolution of closely related species, excluding the aforementioned situations, the frequency of changes in protein evolutionary rates is still not clear at the genome-wide level. Here we examine the constancy of protein evolutionary rates in the evolution of four closely related species of the Saccharomyces sensu stricto group (S. cerevisiae, S. paradoxus, S. mikatae and S. bayanus). RESULTS: For 2,610 unambiguously defined orthologous genes among the four species, we carried out likelihood ratio tests between constant-rate and variable-rate models and found 344 (13.2%) genes showing significant changes in the protein evolutionary rates in at least one lineage. Of all those genes which experienced rate changes, 139 and 49 genes showed accelerated and decelerated evolution, respectively. Most of the evolutionary rate changes could be attributed to changes in selective constraints acting on nonsynonymous sites, independently of species-specific gene duplication and loss. We estimated that the changes in protein evolutionary rates have appeared with a probability of 2.0 × 10(-3 )per gene per million years in the evolution of the Saccharomyces species. Furthermore, we found that the genes which experienced rate acceleration have lower expression levels and weaker codon usage bias than those which experienced rate deceleration. CONCLUSION: Changes in protein evolutionary rates possibly occur frequently in the evolution of closely related Saccharomyces species. Selection for translational accuracy and efficiency may dominantly affect the variability of protein evolutionary rates

Massive double compact object mergers: gravitational wave sources and r-process-element production sites

With our galactic evolutionary code that contains a detailed intermediate mass and massive binary population model, we study the temporal evolution of the galactic population of double neutron star binaries, mixed systems with a neutron star and black hole component and double black hole binaries. We compute the merger rates of these relativistic binaries and we translate them into LIGO II detection rates. We demonstrate that accounting for the uncertainties in the relation 'initial mass-final mass' predicted by massive close binary evolution and due to the possible effect of large stellar wind mass loss during the luminous blue variable phase of a star with initial mass larger than 30-40 Mo and during the red supergiant phase of a star with initial mass smaller than 30-40 Mo when such a star is a binary component, the double black hole merger rate may be very small, contrary to predictions made by other groups. Hydrodynamic computations of r-process chemical yields ejected during the relativistic binary merger process have recently become available. With our galactic code that includes binaries it is then straightforward to calculate the temporal galactic evolution of the r-process elements ejected by these mergers. We conclude that except for the earliest evolutionary phase of the Galaxy (~the first 100 Myr) double compact star mergers may be the major production sites of r-process elements and it is probable that the mixed systems dominate this production over double neutron star binary mergers.Comment: 12 pages, 7 figures, accepted for publication in A&A; accepted versio